Myocardial cell death in reperfused and nonreperfused myocardial infarctions. MR imaging with dysprosioum-DTPA-BMA in the pig.

To investigate whether Dy-DTPA-BMA-enhanced MR imagining would permit identification of myocardial cell death, myocardial infarction was induced in 12 domestic pigs.
In 6 pigs with irreversible cell damage, Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. 70 min after coronary occlusion. In 6 other pigs, the infarctions were reperfused 80 min after the occlusion, followed by injection of Dy-DTPA-BMA after 30 min of reperfusion. In 4 additional pigs, the hearts were reperfused after 2 min of occlusion. All 16 pigs were sacrificed 10 min after the injection of Dy-DTPA-BMA. The hearts were excised and imaged with MR.
Reversibly injured myocardium could not be distinguished from adjacent nonischaemic myocardium after the administration of Dy-DTPA-BMA. Reperfused, infarcted myocardium demonstrated a high signal intensity in the proton-density- and T2-weighted sequences, despite a 5-fold higher Dy concentration compared with both nonreperfused infarcted and nonischaemic myocardium.
This lack of susceptibility effect in infarcted myocardium, due to a homogeneous distribution of Dy, indicates the usefulness of Dy as a marker of tissue viability.
AuthorsS Nilsson, G Wikström, A Ericsson, M Wikström, A Oksendal, A Waldenström, A Hemmingsson
JournalActa radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 37 Issue 1 Pg. 18-26 (Jan 1996) ISSN: 0284-1851 [Print] DENMARK
PMID8611317 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contrast Media
  • Organometallic Compounds
  • sprodiamide
  • Dysprosium
  • Pentetic Acid
  • Animals
  • Cell Death
  • Contrast Media
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Dysprosium
  • Female
  • Magnetic Resonance Angiography (instrumentation, methods)
  • Male
  • Myocardial Infarction (diagnosis, pathology)
  • Myocardial Reperfusion
  • Myocardium (pathology)
  • Organometallic Compounds
  • Pentetic Acid (analogs & derivatives)
  • Swine

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