HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Myocardial cell death in reperfused and nonreperfused myocardial infarctions. MR imaging with dysprosioum-DTPA-BMA in the pig.

AbstractPURPOSE:
To investigate whether Dy-DTPA-BMA-enhanced MR imagining would permit identification of myocardial cell death, myocardial infarction was induced in 12 domestic pigs.
MATERIAL AND METHODS:
In 6 pigs with irreversible cell damage, Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. 70 min after coronary occlusion. In 6 other pigs, the infarctions were reperfused 80 min after the occlusion, followed by injection of Dy-DTPA-BMA after 30 min of reperfusion. In 4 additional pigs, the hearts were reperfused after 2 min of occlusion. All 16 pigs were sacrificed 10 min after the injection of Dy-DTPA-BMA. The hearts were excised and imaged with MR.
RESULTS:
Reversibly injured myocardium could not be distinguished from adjacent nonischaemic myocardium after the administration of Dy-DTPA-BMA. Reperfused, infarcted myocardium demonstrated a high signal intensity in the proton-density- and T2-weighted sequences, despite a 5-fold higher Dy concentration compared with both nonreperfused infarcted and nonischaemic myocardium.
CONCLUSION:
This lack of susceptibility effect in infarcted myocardium, due to a homogeneous distribution of Dy, indicates the usefulness of Dy as a marker of tissue viability.
AuthorsS Nilsson, G Wikström, A Ericsson, M Wikström, A Oksendal, A Waldenström, A Hemmingsson
JournalActa radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 37 Issue 1 Pg. 18-26 (Jan 1996) ISSN: 0284-1851 [Print] DENMARK
PMID8611317 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contrast Media
  • Organometallic Compounds
  • sprodiamide
  • Dysprosium
  • Pentetic Acid
Topics
  • Animals
  • Cell Death
  • Contrast Media
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Dysprosium
  • Female
  • Magnetic Resonance Angiography (instrumentation, methods)
  • Male
  • Myocardial Infarction (diagnosis, pathology)
  • Myocardial Reperfusion
  • Myocardium (pathology)
  • Organometallic Compounds
  • Pentetic Acid (analogs & derivatives)
  • Swine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: