Abstract | BACKGROUND: METHODS: RESULTS: EGCG and GRE inhibited chemical carcinogenesis of the gastrointestinal tract in rodents. Judging from the epidemiologic and experimental findings, it was determined that 1 g per day of GTE might be an effective dose. GTE was not toxic and no harmful effect was found during its clinical use. CONCLUSIONS: These findings suggest that EGCG and GTE are useful in preventing gastrointestinal carcinogenesis, and the clinical usefulness of GTE, which has no harmful effects and is inexpensive, should be studied further.
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Authors | T Yamane, H Nakatani, N Kikuoka, H Matsumoto, Y Iwata, Y Kitao, K Oya, T Takahashi |
Journal | Cancer
(Cancer)
Vol. 77
Issue 8 Suppl
Pg. 1662-7
(Apr 15 1996)
ISSN: 0008-543X [Print] United States |
PMID | 8608559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticarcinogenic Agents
- Carcinogens
- Plant Extracts
- Tea
- Methylnitronitrosoguanidine
- ENNG
- Catechin
- epigallocatechin gallate
- Azoxymethane
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Topics |
- Animals
- Anticarcinogenic Agents
(therapeutic use)
- Azoxymethane
- Carcinogens
(toxicity)
- Catechin
(analogs & derivatives, therapeutic use, toxicity)
- Gastrointestinal Neoplasms
(chemically induced, prevention & control)
- Male
- Methylnitronitrosoguanidine
(analogs & derivatives)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutagenicity Tests
- Plant Extracts
(therapeutic use, toxicity)
- Rats
- Rats, Inbred F344
- Rats, Sprague-Dawley
- Tea
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