Abstract | BACKGROUND: METHODS: RESULTS: Patients with nonresectable HCC showed a significant increase in 6 beta OHF excretion as well as their 6 beta OHF/F ratio (P < 0.05) when compared with the controls and other liver disease groups including patients with resectable HCC. The nonresectable HCC group showed a bimodal distribution in the 6 beta OHF/F ratio. Using a ratio of 9 or more in all HCC patients, the sensitivity and specificity of using the 6 beta OHF/F ratio to predict nonresectability of HCC was 48.8% and 92.6%, respectively. CONCLUSIONS: Our results show an increase in mean CYP3A4 enzyme activity, reflected as an increase in the 6 beta OHF/F ratio, in Hong Kong Chinese with nonresectable HCC compared with those with resectable HCC and other liver diseases. Although the role of increased CYP3A4 activity in the aetiology of HCC is not known, our specificity and sensitivity estimates suggest that a high 6 beta OHF/F ratio indicates probable inoperability. However, a normal level is a poor predictor of resectability.
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Authors | M C Ng, R P Young, J A Critchley, N W Leung, J W Lau, A K Li |
Journal | Cancer
(Cancer)
Vol. 77
Issue 8
Pg. 1427-33
(Apr 15 1996)
ISSN: 0008-543X [Print] United States |
PMID | 8608525
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoenzymes
- 6 beta-hydroxycortisol
- Cytochrome P-450 Enzyme System
- Mixed Function Oxygenases
- Cytochrome P-450 CYP2E1
- Hydrocortisone
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(enzymology, urine)
- China
(ethnology)
- Chronic Disease
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
(metabolism)
- Female
- Hong Kong
- Humans
- Hydrocortisone
(analogs & derivatives, urine)
- Isoenzymes
(metabolism)
- Liver Diseases
(enzymology, urine)
- Liver Neoplasms
(enzymology, urine)
- Male
- Middle Aged
- Mixed Function Oxygenases
(metabolism)
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