HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists.

Abstract
We have used a number of approaches to address a possible role of metabotropic glutamate receptors (mGluRs) in mossy fiber long-term potentiation (LTP) in the hippocampus. We have used two types of mutant mice--one lacking the mGluR1 subtype of receptor and one lacking the gamma isoform of protein kinase C. In neither type of mouse did we find any alteration in the magnitude of mossy fiber LTP. We next examined whether mGluRs might modulate the magnitude and/or threshold for the induction of mossy fiber LTP. In these experiments we used tetani that were either just subthreshold or just suprathreshold for generating LTP. The mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine [(+)MCPG] did not convert a subthreshold tetanus into a suprathreshold tetanus, nor did (+)MCPG have any effect on the small amount of LTP that was generated by a just suprathreshold tetanus. Based on our studies, we have been unable to identify a role for mGluRs in mossy fiber LTP.
AuthorsA Y Hsia, P A Salin, P E Castillo, A Aiba, A Abeliovich, S Tonegawa, R A Nicoll
JournalNeuropharmacology (Neuropharmacology) Vol. 34 Issue 11 Pg. 1567-72 (Nov 1995) ISSN: 0028-3908 [Print] England
PMID8606804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Benzoates
  • Excitatory Amino Acid Antagonists
  • Receptors, Metabotropic Glutamate
  • alpha-methyl-4-carboxyphenylglycine
  • Protein Kinase C
  • Glycine
Topics
  • Animals
  • Benzoates (pharmacology)
  • Excitatory Amino Acid Antagonists (pharmacology)
  • Glycine (analogs & derivatives, pharmacology)
  • Hippocampus (physiology)
  • In Vitro Techniques
  • Long-Term Potentiation (physiology)
  • Mice
  • Mice, Knockout
  • Protein Kinase C (physiology)
  • Receptors, Metabotropic Glutamate (antagonists & inhibitors, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: