Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.

Abstract

Reactivation of Chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected NIH/s mice. The treatment started 2 or 4 weeks after primary infection, when no C. pneumoniae was detected. C. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. These results confirm the persistent nature of C. pneumoniae infection.

• Authors: K Laitinen, A L Laurila, M Leinonen, P Saikku
• Journal: Infection and immunity (Infect Immun) Vol. 64 Issue 4 Pg. 1488-90 (Apr 1996) ISSN: 0019-9567 [Print] United States
• PMID: 8606126 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• Cortisone

Topics

• Animals
• Chlamydia Infections (etiology, immunology)
• Chlamydophila pneumoniae
• Cortisone (pharmacology)
• Female
• Immunosuppressive Agents (pharmacology)
• Mice