Abstract | BACKGROUND: STUDY DESIGN: Total hepatic ischemia was produced in rats for 90 minutes using an extracorporeal portosystemic shunt. To assess the role of SLe(x) in hepatic ischemia and reperfusion injury, 25 mg/kg of an SLe(x) analog, CY-1503, was given five minutes before reperfusion or at reperfusion. Biochemical tests of hepatic injury, myeloperoxidase activity in hepatic tissue, and histologic studies, including neutrophil infiltration determined by the naphthol esterase technique, were analyzed six hours after reperfusion. RESULTS: CONCLUSIONS:
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Authors | K Misawa, L H Toledo-Pereyra, M L Phillips, F J Garcia-Cirado, F Lopez-Neblina, A Paez-Rollys |
Journal | Journal of the American College of Surgeons
(J Am Coll Surg)
Vol. 182
Issue 3
Pg. 251-6
(Mar 1996)
ISSN: 1072-7515 [Print] United States |
PMID | 8603246
(Publication Type: Journal Article)
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Chemical References |
- CY 1503
- Lewis Blood Group Antigens
- Ligands
- Oligosaccharides
- Selectins
- Sialyl Lewis X Antigen
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Topics |
- Animals
- Drug Evaluation, Preclinical
- Endothelium, Vascular
(drug effects, metabolism)
- Ischemia
(drug therapy, metabolism, pathology)
- Lewis Blood Group Antigens
- Ligands
- Liver
(blood supply, enzymology, pathology)
- Male
- Neutrophils
(drug effects, metabolism)
- Oligosaccharides
(metabolism, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(drug therapy, metabolism, pathology)
- Selectins
(metabolism)
- Sialyl Lewis X Antigen
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