Abstract |
The effect of dietary MaxEPA ( fish oil) supplementation on cholesterol induced hypercholesterolemia in rabbits was investigated. Rabbits were fed 0.1% cholesterol enriched diet for one month and randomly divided into two groups (I and II). Group I was continued on a 0.1% cholesterol rich diet whereas group II in addition to cholesterol supplementation received MaxEPA (2.5 g/kg body weight) per day for a period of two months. B-VLDL-C, LDL-C and total serum peroxide levels ( TBARS) were significantly higher in group II animals as compared to group I. No statistical difference was found in the number of hepatic B-VLDL binding sites between group I and II. Microscopic examination of the aorta showed an increase in the number of intimal foam cells in MaxEPA treated group, a result that may be linked to increase in total cholesterol, plasma TBARS and with simultaneous reduced hepatic uptake of B-VLDL.
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Authors | C Achtani, A Awtade, S Vasisht, L M Srivastava |
Journal | Biochemistry and molecular biology international
(Biochem Mol Biol Int)
Vol. 37
Issue 3
Pg. 489-98
(Oct 1995)
ISSN: 1039-9712 [Print] England |
PMID | 8595389
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, Dietary
- Dietary Fats, Unsaturated
- Drug Combinations
- Fatty Acids, Omega-3
- Fish Oils
- Lipoproteins
- Maxepa
- Receptors, Lipoprotein
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
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Topics |
- Animals
- Cholesterol, Dietary
(adverse effects)
- Dietary Fats, Unsaturated
(pharmacology)
- Docosahexaenoic Acids
- Drug Combinations
- Eicosapentaenoic Acid
- Fatty Acids, Omega-3
(analysis, chemistry, pharmacology)
- Fish Oils
(chemistry, pharmacology)
- Hypercholesterolemia
(diet therapy, etiology)
- Lipoproteins
(blood)
- Male
- Protein Binding
- Rabbits
- Receptors, Lipoprotein
(metabolism)
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