Abstract |
Monoclonal antibody MR6 detects gp200-MR6, a molecule functionally associated with the interleukin 4 (IL- 4) receptor. Positive immunolabeling with MAb MR6 was obtained in 28/28 transitional cell carcinomas of the bladder, representing a range of different grades and stages of disease, as well as in all control non-neoplastic urothelia. The expression of mutant p53 protein and epidermal growth factor receptor was detected in 14/28 and 20/28 cases respectively. Proliferation indices, determined by Ki67 labeling, ranged from 5% to 95% among these tumours. The universal expression of gp200-MR6 in neoplastic and non-neoplastic urothelium has important implications for the possible use of IL-4 in tumour therapy and suggests that IL- 4 may play a role in differentiation and homeostasis of urothelium and other mucosal epithelia.
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Authors | M F Tungekar, K C Gatter, M A Ritter |
Journal | British journal of cancer
(Br J Cancer)
Vol. 73
Issue 4
Pg. 429-32
(Feb 1996)
ISSN: 0007-0920 [Print] England |
PMID | 8595155
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Neoplasm
- Antigens, Surface
- DEC-205 receptor
- Glycoproteins
- Lectins, C-Type
- Minor Histocompatibility Antigens
- Receptors, Cell Surface
- Receptors, Interleukin
- Receptors, Interleukin-4
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Topics |
- Antibodies, Monoclonal
(immunology)
- Antigens, CD
(metabolism)
- Antigens, Neoplasm
(biosynthesis, immunology)
- Antigens, Surface
(biosynthesis, immunology)
- Carcinoma, Transitional Cell
(immunology, metabolism, pathology, surgery)
- Epithelium
(immunology, metabolism, pathology)
- Glycoproteins
(biosynthesis, immunology)
- Humans
- Lectins, C-Type
- Minor Histocompatibility Antigens
- Neoplasm Invasiveness
- Receptors, Cell Surface
- Receptors, Interleukin
(metabolism)
- Receptors, Interleukin-4
- Urinary Bladder
(immunology, metabolism, pathology)
- Urinary Bladder Neoplasms
(immunology, metabolism, pathology, surgery)
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