Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124).

Abstract

Monoclonal antibody MR6 detects gp200-MR6, a molecule functionally associated with the interleukin 4 (IL- 4) receptor. Positive immunolabeling with MAb MR6 was obtained in 28/28 transitional cell carcinomas of the bladder, representing a range of different grades and stages of disease, as well as in all control non-neoplastic urothelia. The expression of mutant p53 protein and epidermal growth factor receptor was detected in 14/28 and 20/28 cases respectively. Proliferation indices, determined by Ki67 labeling, ranged from 5% to 95% among these tumours. The universal expression of gp200-MR6 in neoplastic and non-neoplastic urothelium has important implications for the possible use of IL-4 in tumour therapy and suggests that IL- 4 may play a role in differentiation and homeostasis of urothelium and other mucosal epithelia.

• Authors: M F Tungekar, K C Gatter, M A Ritter
• Journal: British journal of cancer (Br J Cancer) Vol. 73 Issue 4 Pg. 429-32 (Feb 1996) ISSN: 0007-0920 [Print] England
• PMID: 8595155 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antigens, CD
• Antigens, Neoplasm
• Antigens, Surface
• DEC-205 receptor
• Glycoproteins
• Lectins, C-Type
• Minor Histocompatibility Antigens
• Receptors, Cell Surface
• Receptors, Interleukin
• Receptors, Interleukin-4

Topics

• Antibodies, Monoclonal (immunology)
• Antigens, CD (metabolism)
• Antigens, Neoplasm (biosynthesis, immunology)
• Antigens, Surface (biosynthesis, immunology)
• Carcinoma, Transitional Cell (immunology, metabolism, pathology, surgery)
• Epithelium (immunology, metabolism, pathology)
• Glycoproteins (biosynthesis, immunology)
• Humans
• Lectins, C-Type
• Minor Histocompatibility Antigens
• Neoplasm Invasiveness
• Receptors, Cell Surface
• Receptors, Interleukin (metabolism)
• Receptors, Interleukin-4
• Urinary Bladder (immunology, metabolism, pathology)
• Urinary Bladder Neoplasms (immunology, metabolism, pathology, surgery)