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Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia.

Abstract
Ten known glycosidic compounds, betulalbuside A (1), 8-hydroxylinaloyl,3-O-beta-D-glucopyranoside (2) (monoterpen glycosides), ipolamide (3) (iridoid glycoside), acteoside (verbascoside) (4), leucosceptoside A (5), martynoside (6), forsythoside B (7), phlinoside B (8), phlinoside C (9), and teuerioside (10) (phenylpropanoid glycosides) were isolated from methanolic extracts of Phlomis armeniaca and Scutellaria salviifolia (Labiatae). Structure elucidations were carried out using 1H-, 13C-NMR and FAB-MS spectra, as well as chemical evidence. The cytotoxic and cytostatic activities of isolated compounds were investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. Among the glycosides obtained here, caffeic acid-containing phenylpropanoid (or phenethyl alcohol, or phenylethanoid) glycosides were found to show activity against several kinds of cancer cells. However, they didn't affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.
AuthorsI Saracoglu, M Inoue, I Calis, Y Ogihara
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 18 Issue 10 Pg. 1396-400 (Oct 1995) ISSN: 0918-6158 [Print] Japan
PMID8593444 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Plant Extracts
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Glycosides (chemistry, isolation & purification, pharmacology)
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Plant Extracts (chemistry, isolation & purification, pharmacology)
  • Plants, Medicinal (chemistry)
  • Rats
  • Tumor Cells, Cultured
  • Turkey

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