Abstract |
Ten known glycosidic compounds, betulalbuside A (1), 8-hydroxylinaloyl,3-O-beta-D-glucopyranoside (2) (monoterpen glycosides), ipolamide (3) ( iridoid glycoside), acteoside ( verbascoside) (4), leucosceptoside A (5), martynoside (6), forsythoside B (7), phlinoside B (8), phlinoside C (9), and teuerioside (10) (phenylpropanoid glycosides) were isolated from methanolic extracts of Phlomis armeniaca and Scutellaria salviifolia (Labiatae). Structure elucidations were carried out using 1H-, 13C-NMR and FAB-MS spectra, as well as chemical evidence. The cytotoxic and cytostatic activities of isolated compounds were investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. Among the glycosides obtained here, caffeic acid-containing phenylpropanoid (or phenethyl alcohol, or phenylethanoid) glycosides were found to show activity against several kinds of cancer cells. However, they didn't affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.
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Authors | I Saracoglu, M Inoue, I Calis, Y Ogihara |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 18
Issue 10
Pg. 1396-400
(Oct 1995)
ISSN: 0918-6158 [Print] Japan |
PMID | 8593444
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Glycosides
- Plant Extracts
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology)
- Drug Screening Assays, Antitumor
- Glycosides
(chemistry, isolation & purification, pharmacology)
- Humans
- Magnetic Resonance Spectroscopy
- Mice
- Plant Extracts
(chemistry, isolation & purification, pharmacology)
- Plants, Medicinal
(chemistry)
- Rats
- Tumor Cells, Cultured
- Turkey
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