Accumulation of protoporphyrin isomers I and III, and multiple decarboxylation products of uroporphyrin in a case of porphyria in a slaughtered pig.

Abstract

Pathological and biochemical examinations were made on tissues from a case of porphyria in a slaughtered pig. Bones, kidneys, teeth and lymph nodes showed a mahogany discoloration. Histologically, the pigment was negative on staining for iron (Gomori) and showed a strong red-orange fluorescence under UV light proving it to be porphyrin. Biochemical studies on the kidney, lymph nodes, bone and bone marrow revealed a 'mixed' erythropoietic protoporphyria-coproporphyria. This indicates that the case presented probably represented both a uroporphyrinogen decarboxylase and uroporphyrinogen-III-cosynthase dysfunction.

• Authors: S Roels, A Hassoun, J Hoorens
• Journal: Zentralblatt fur Veterinarmedizin. Reihe A (Zentralbl Veterinarmed A) Vol. 42 Issue 2 Pg. 145-51 (Apr 1995) ISSN: 0514-7158 [Print] Germany
• PMID: 8592889 (Publication Type: Journal Article)

Chemical References

• Protoporphyrins
• Uroporphyrins

Topics

• Abattoirs
• Animals
• Bone and Bones (metabolism)
• Decarboxylation
• Female
• Isomerism
• Kidney (metabolism)
• Lymph Nodes (metabolism)
• Porphyrias (metabolism, pathology, veterinary)
• Protoporphyrins (chemistry, metabolism)
• Swine
• Swine Diseases (metabolism, pathology)
• Tooth (metabolism)
• Uroporphyrins (metabolism)