Efficacy of oral citrate administration in primary hyperoxaluria.

Abstract

Urinary citrate is a potent inhibitor of calcium oxalate (CaOx) crystallization, but oral citrate has rarely been used in patients with primary hyperoxaluria (PH). We studied the effect of sodium citrate administration (0.1-0.15 g/kg/day) on urinary citrate excretion and CaOx saturation in seven paediatric patients and the clinical response to long-term treatment (average 4 years) in five patients. Urinary citrate increased from 0.73 to 2.54 mmol/24 h/1.73 m2 and urinary saturation for CaOx (calculated by equil 2) decreased from 11.41 to 6.79 (for both, p < 0.02). Long-term administration of alkali citrate [0.15 g (0.5 mmol)/kg/day] resulted in stable or improved renal function in three and slow deterioration in two partially non-compliant patients. Alkali citrate is effective in patients with PH.

• Authors: E Leumann, B Hoppe, T Neuhaus, N Blau
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 10 Suppl 8 Pg. 14-6 ( 1995) ISSN: 0931-0509 [Print] England
• PMID: 8592618 (Publication Type: Journal Article)

Chemical References

• Citrates
• Calcium Oxalate
• Citric Acid

Topics

• Administration, Oral
• Adolescent
• Calcium Oxalate (urine)
• Child
• Child, Preschool
• Citrates (therapeutic use, urine)
• Citric Acid
• Female
• Humans
• Hyperoxaluria, Primary (drug therapy, physiopathology, urine)
• Kidney (physiopathology)
• Male
• Treatment Outcome