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Visual function in recovered ethambutol optic neuropathy.

Abstract
The visual acuity of the patient with ethambutol optic neuropathy will recover within 3 to 4 months after discontinuing the drug. We studied the extent of the recovery of other visual functions. Thirty-six axial type ethambutol optic neuropathy patients, who visited our neuro-ophthalmology clinic from January, 1990, to December, 1993, were included in this study. Fifteen patients (29 eyes) regained their visual acuity to better than 1.0. The average follow-up period following the recovery is 21.7 months. Pattern reversal VEP, Farnsworth-Munsell 100-Hue color vision test, critical flicker frequency (CFF), visual field perimetry, contrast sensitivity and edge-light pupil cycle time were assessed for every affected eye. Latency (P100) of visually evoked potential was delayed in 34.5% (10/29) of eyes. In color vision, 48.3% (14/29) of eyes had deutan or tritan defect. An abnormality of red CFF with value lower than 31 Hz was revealed 51.7% (15/29) eyes. In the visual field, 58.6% (17/29) of eyes had paracentral scotoma, arcuate scotoma, or enlargement of physiologic blind spot. Contrast sensitivity was depressed in 62.1% (18/29) of eyes, mainly at middle and low spatial frequency. Pupil cycle time was prolonged in 72.4% (21/29) of eyes. Aside from visual acuity, other visual functions of the recovered ethambutol optic neuropathy patients were incomplete. The extent of recovery of the visual function is as follows: visual acuity-VEPs-color sense-CFF-visual field-contrast sensitivity-pupil cycle time.
AuthorsL C Woung, J R Jou, S L Liaw
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 11 Issue 3 Pg. 411-9 ( 1995) ISSN: 1080-7683 [Print] United States
PMID8590273 (Publication Type: Journal Article)
Chemical References
  • Antitubercular Agents
  • Ethambutol
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents (adverse effects)
  • Color Perception (physiology)
  • Contrast Sensitivity (physiology)
  • Ethambutol (adverse effects)
  • Evoked Potentials, Visual (physiology)
  • Female
  • Flicker Fusion (physiology)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Optic Nerve Diseases (chemically induced, physiopathology)
  • Tuberculosis, Pulmonary (drug therapy, physiopathology)
  • Visual Acuity (physiology)
  • Visual Field Tests
  • Visual Fields (physiology)

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