Effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism.

Abstract

Ifenprodil, a cerebral vasodilator and non-competitive glutamate antagonist, is also an anti-ischaemic agent; it has been shown to inhibit both forms of MAO in rat brain and lung (with slightly greater potency towards MAO-A), but it does not inhibit SSAO. The effects of ifenprodil on rat brain regional levels of monoamines and their principal metabolites following transient global ischaemia have been investigated 1 h after reperfusion. Among the three most ischaemically vulnerable brain regions (striatum, hippocampus and cortex), striatal DA, DOPAC, HVA, 5-HT and 5-HIAA levels were the most markedly increased. Simultaneous treatment with ifenprodil during reperfusion reversed the increases in the striatum, except for HVA, to the level similar to those of sham-operated controls. In contrast to the striatum, ifenprodil failed to reverse the increases seen in the cortex and hippocampus.

• Authors: T Tadano, A Yonezawa, K Oyama, K Kisara, Y Arai, M Togashi, H Kinemuchi
• Journal: Progress in brain research (Prog Brain Res) Vol. 106 Pg. 173-80 ( 1995) ISSN: 0079-6123 [Print] Netherlands
• PMID: 8584652 (Publication Type: Journal Article)

Chemical References

• Monoamine Oxidase Inhibitors
• Piperidines
• ifenprodil

Topics

• Animals
• Brain (drug effects)
• Brain Ischemia (metabolism)
• Hippocampus (drug effects)
• Male
• Monoamine Oxidase Inhibitors (pharmacology)
• Piperidines (pharmacology)
• Rats
• Rats, Wistar