Bartonella henselae is an etiologic agent of
cat-scratch disease and, in immunocompromised patients, of
bacillary angiomatosis and other severe syndromes.
Cat-scratch disease usually presents as
lymphadenopathy, which resolves spontaneously within 2-4 months. The utility of
antibiotic therapy remains controversial. In Tyrol four cases of human
cat-scratch disease were diagnosed in children in 1994, yielding a prevalence of 0.7/100,000 per year. A 3-year-old boy had
lymphadenitis coli since one year despite antituberculosis
therapy which was initiated because of the histopathological picture and a positive
tuberculin reaction (despite negative mycobacteria-cultures and -PCR). Two girls, age 9 and 13 years, had
lymphadenitis at upper or lower extremities after cat-scratches from kittens. A 13-year-old boy presented with febrile illness and right hip
pain, computer tomography revealed an osteolytic lesion; symptoms subsided within 3 weeks. Diagnosis of
cat-scratch disease is based on cat contact, negative studies for other similar diseases, characteristic histopathologic features (if available), and results of an indirect immunofluorescence test (
antigen: Houston-1 isolate, ATCC 49882). We believe that the availability of this serological test will increase the number of diagnosed cases of human
Bartonella henselae infections.