Deleterious effect of formycin A on tumor islet cells.

Abstract

The adenosine analogue formycin A was recently introduced as a potent insulin secretagogue in normal pancreatic islet cells. In the present study, formycin A was found to inhibit insulin release and to exert a cytotoxic effect in tumor islet cells of the RINm5F line. The latter effect was concentration-related in the 10-100 microM range of formycin A concentrations, not rapidly reversed, and not reproduced by adenosine. This study thus reveals that formycin A may display cytotoxic potential in the same range of concentrations in which it causes a progressive increase of glucose-stimulated insulin secretion in normal pancreatic islets.

• Authors: J Rasschaert, K Tanigawa, W J Malaisse
• Journal: Biochemical and molecular medicine (Biochem Mol Med) Vol. 54 Issue 2 Pg. 138-41 (Apr 1995) ISSN: 1077-3150 [Print] United States
• PMID: 8581359 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Formycins
• Insulin
• Proteins
• formycin
• Adenosine

Topics

• Adenoma, Islet Cell (drug therapy)
• Adenosine (analogs & derivatives)
• Animals
• Antineoplastic Agents (pharmacology)
• Formycins (pharmacology)
• Insulin (chemistry, metabolism)
• Insulin Secretion
• Pancreatic Neoplasms (chemistry, drug therapy, pathology)
• Proteins (chemistry, drug effects)
• Tumor Cells, Cultured