Ceroid pigment deposition in circulating blood monocytes and T lymphocytes in Hermansky-Pudlak syndrome: an ultrastructural study.

Abstract

An electron microscopic study of peripheral leukocytes obtained from a 39 year old woman with Hermansky-Pudlak syndrome was performed. Ceroid pigment granules were found within the lysosomes in 3.5% of monocytes and 5.4% of lymphocytes. Infrequently, pigment granules were also found in the parallel tubular arrays of lymphocytes. The lymphocytes containing ceroid pigment granules were confirmed to be T cells by immunoelectron microscopy. It was speculated that intralysosomal accumulation of ceroid pigment granules in Hermansky-Pudlak syndrome may be due to lysosomal dysfunction.

• Authors: T Sakuma, N Monma, R Satodate, T Satoh, R Takeda, S Kuriya
• Journal: Pathology international (Pathol Int) Vol. 45 Issue 11 Pg. 866-70 (Nov 1995) ISSN: 1320-5463 [Print] Australia
• PMID: 8581150 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ceroid

Topics

• Adult
• Albinism, Oculocutaneous (immunology, pathology)
• Ceroid (blood)
• Female
• Humans
• Microscopy, Immunoelectron
• Monocytes (chemistry, ultrastructure)
• T-Lymphocytes (chemistry, ultrastructure)