P1 blood group antigen expression and epidemic hemolytic uremic syndrome.

Abstract

P1 blood group positivity has been postulated as a host factor which may provide protection against the development of post-enteropathic hemolytic uremic syndrome (HUS). In this study, blood group status in 20 Inuit survivors of Escherichia coli O157:H7-associated HUS was compared with age- and sex-matched controls from the same community who had experienced uncomplicated diarrheal illness due to the same pathogen. Of 20 HUS survivors, 6 were P1 antigen positive compared with 8 of the 20 controls (P = 0.7). We conclude that P1 antigen positivity was not protective against HUS in this population. Further studies of this condition to clarify the role of host factors in verotoxin-induced endothelial damage are indicated.

• Authors: P H Orr, V Dong, M L Schroeder, M R Ogborn
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 9 Issue 5 Pg. 612-3 (Oct 1995) ISSN: 0931-041X [Print] Germany
• PMID: 8580022 (Publication Type: Journal Article)

Chemical References

• Antigens, Nuclear
• Autoantigens
• Bacterial Toxins
• Enterotoxins
• Nuclear Proteins
• Shiga Toxin 1

Topics

• Aged
• Antigens, Nuclear
• Autoantigens (blood)
• Bacterial Toxins (blood)
• Canada (epidemiology)
• Case-Control Studies
• Child
• Child, Preschool
• Disease Outbreaks
• Enterotoxins (blood)
• Escherichia coli
• Female
• Follow-Up Studies
• Gastroenteritis (complications, epidemiology, immunology, microbiology)
• Hemolytic-Uremic Syndrome (epidemiology, immunology, microbiology)
• Humans
• Infant
• Male
• Nuclear Proteins (blood)
• Shiga Toxin 1