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Sucralfate: prophylaxis of mucosal damage during cancer therapy.

AbstractBACKGROUND:
Chemotherapy and radiotherapy of different malignancies may be complicated by a variety of side effects, some of which may be related mucosal damage.
RESULTS:
There is increasing evidence that sucralfate reduces the severity of radiation-induced mucositis in the head and neck, esophagus, and the lower gastrointestinal tract. Sucralfate also seems to protect the skin during radiotherapy and to reduce chemotherapy-induced mucositis.
CONCLUSION:
Further studies could be of interest to define the clinical significance of sucralfate in reducing the mucosal damage and increasing quality of life during an following cancer therapy.
AuthorsR Henriksson, L Franzén, C Edbom, B Littbrand
JournalScandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 210 Pg. 45-7 ( 1995) ISSN: 0085-5928 [Print] NORWAY
PMID8578206 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Ulcer Agents
  • Antineoplastic Agents
  • Sucralfate
Topics
  • Anti-Ulcer Agents (administration & dosage, therapeutic use)
  • Antineoplastic Agents (adverse effects)
  • Humans
  • Intestinal Diseases (etiology, prevention & control)
  • Intestinal Mucosa (drug effects, pathology)
  • Neoplasms (therapy)
  • Radiotherapy (adverse effects)
  • Sucralfate (administration & dosage, therapeutic use)

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