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Elastosis perforans serpiginosa induced by penicillamine.

Abstract
A patient with Wilson disease, under prolonged treatment with penicillamine, developed lesions of elastosis perforans serpiginosa (EPS). Examination of biopsy specimens by light microscopy revealed the characteristic changes of EPS. Examination by transmission electron microscopy revealed structural changes in the elastic fibers not previously described. The appearance of the lesions by scanning electron microscopy is described for the first time. It is suggested that penicillamine induced EPS may be morphologically distinct from the idiopathic form.
AuthorsN Kirsch, P B Hukill
JournalArchives of dermatology (Arch Dermatol) Vol. 113 Issue 5 Pg. 630-5 (May 1977) ISSN: 0003-987X [Print] United States
PMID857731 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Penicillamine
Topics
  • Adult
  • Elastic Tissue
  • Hepatolenticular Degeneration (drug therapy)
  • Humans
  • Male
  • Penicillamine (adverse effects, therapeutic use)
  • Skin (ultrastructure)
  • Skin Diseases (chemically induced)

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