[Immunologic transformation against pertussis in children following a second revaccination with ADPT-vaccine].

Abstract

Immunological reconstruction was studied in children aged 6 years after the second revaccination with absorbed, pertussis-diphtheria-tetanus vaccine (APDT) in a strictly controlled trial. Antipertussis protective antibodies were determined in the sera in the passive hemagglutination test and the antigen neutralization test, whose results were characterized by the following regularities: the average (1:160--1:640) and the high (1:1280 and over) antibody titres were recorded 1 to 1.5 months after the vaccination in 46.9--48.9% of the persons vaccinated. Determination of the changes of the immunoglobulins A, M, and G at various periods after the second revaccination demonstrated that 1 to 1.5 months after the revaccination (that is at the peak of the antipertussis antibodies formation) 55.7--50.0% of the children displayed an elevation of the IgA and IgM against the background of the IgG reduction in 69.7% of cases.

• Authors: E A Baeva, I Z Aleksandrova, T S Selezneva
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 2 Pg. 104-8 (Feb 1977) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Osobennosti immunologicheskoĭ perestroĭki protiv kokliusha u deteĭ posle vtoroĭ revaktsinatsii AKDS-vaktsinoĭ
• PMID: 857515 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• Pertussis Vaccine

Topics

• Antibodies, Bacterial (analysis)
• Child
• Hemagglutination Tests
• Humans
• Immunization Schedule
• Immunization, Secondary
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Neutralization Tests
• Pertussis Vaccine (administration & dosage)
• Time Factors
• Whooping Cough (immunology, prevention & control)