Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori.

Abstract

OBJECTIVE:

To investigate the effect of plaunotol in combination with proton-pump inhibitors on Helicobacter pylori eradication in patients with gastric ulcer.

PATIENTS AND METHODS:

We studied 65 H. pylori-positive gastric ulcer patients. They were randomly assigned to five treatment groups: omeprazole (group I, n = 8), lansoprazole (group II, n = 13), lansoprazole+plaunotol (group III, n = 12), lansoprazole+clarithromycin (group IV, n = 16) and lansoprazole+plaunotol+clarithromycin (group V, n = 16). Ulcer status was diagnosed by endoscopy and H. pylori status by culture, histology, a urease test and a urea breath test at baseline, and after 8 and 12 weeks. The clearance and eradication rates were compared in each group.

RESULTS:

The healing rates in groups I-V were 100, 92, 100, 100 and 100%, respectively; clearance rates were 0, 23, 42, 50 and 75%, respectively; and eradication rates were 0, 0, 8, 38 and 69%, respectively.

CONCLUSION:

Combination therapy with plaunotol is efficacious for the eradication of H. pylori in gastric ulcer patients.

• Authors: Y Fukuda, I Yamamoto, M Okui, Y Tonokatsu, K Tamura, T Shimoyama
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 7 Suppl 1 Pg. S45-7 (Aug 1995) ISSN: 0954-691X [Print] England
• PMID: 8574735 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Diterpenes
• Fatty Alcohols
• Clarithromycin
• plaunotol

Topics

• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Anti-Ulcer Agents (administration & dosage, therapeutic use)
• Biopsy
• Clarithromycin (administration & dosage, therapeutic use)
• Colony Count, Microbial
• Diterpenes
• Drug Therapy, Combination
• Fatty Alcohols (administration & dosage, therapeutic use)
• Gastric Mucosa (drug effects, microbiology)
• Gastroscopy
• Helicobacter Infections (complications, drug therapy, microbiology)
• Helicobacter pylori (drug effects, isolation & purification)
• Humans
• Stomach Ulcer (drug therapy, microbiology)