Abstract | OBJECTIVE: PATIENTS AND METHODS: We studied 65 H. pylori-positive gastric ulcer patients. They were randomly assigned to five treatment groups: omeprazole (group I, n = 8), lansoprazole (group II, n = 13), lansoprazole+plaunotol (group III, n = 12), lansoprazole+clarithromycin (group IV, n = 16) and lansoprazole+ plaunotol+ clarithromycin (group V, n = 16). Ulcer status was diagnosed by endoscopy and H. pylori status by culture, histology, a urease test and a urea breath test at baseline, and after 8 and 12 weeks. The clearance and eradication rates were compared in each group. RESULTS: The healing rates in groups I-V were 100, 92, 100, 100 and 100%, respectively; clearance rates were 0, 23, 42, 50 and 75%, respectively; and eradication rates were 0, 0, 8, 38 and 69%, respectively. CONCLUSION:
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Authors | Y Fukuda, I Yamamoto, M Okui, Y Tonokatsu, K Tamura, T Shimoyama |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 7 Suppl 1
Pg. S45-7
(Aug 1995)
ISSN: 0954-691X [Print] England |
PMID | 8574735
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Diterpenes
- Fatty Alcohols
- Clarithromycin
- plaunotol
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Topics |
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Biopsy
- Clarithromycin
(administration & dosage, therapeutic use)
- Colony Count, Microbial
- Diterpenes
- Drug Therapy, Combination
- Fatty Alcohols
(administration & dosage, therapeutic use)
- Gastric Mucosa
(drug effects, microbiology)
- Gastroscopy
- Helicobacter Infections
(complications, drug therapy, microbiology)
- Helicobacter pylori
(drug effects, isolation & purification)
- Humans
- Stomach Ulcer
(drug therapy, microbiology)
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