Effects on metabolic rate and fuel selection of a selective beta-3 agonist (ICI D7114) in healthy lean men.

Abstract

METHOD:

ICI D7114 is a selective beta-3 agonist which in some animals increases metabolic rate, promotes weight loss and improves glucose tolerance. To investigate its potential usefulness in humans, 16 healthy young men (mean age 28.9 +/- 8.0 years; body mass index 22.5 +/- 1.6 kg/m2) were given ICI D7114 (150 mg/day, 2.08 +/- 0.24 mg/kg body weight) or placebo for 14 days in a double-blind randomised parallel group trial. Energy expenditure (EE) and substrate oxidation were assessed by continuous whole-body indirect calorimetry on Day 0 (before dosing), on day 1 (acute effect) and on Day 14 (chronic effect).

RESULTS:

Analysis of covariance indicated no significant effects on EE 4 h post-dose (Day 1, +2.4%, NS; Day 14, +1.0%, NS). There was no chronic effect on either the lowest 1 h of sleeping EE (+2.2%, NS) or 24 h EE (+0.7%, NS). There was a marginally significant chronic stimulation of basal metabolic rate (+3.6%, P = 0.042). ICI D7114 had no significant influence on protein, fat or carbohydrate oxidation. Tolerability and safety data showed that there were no increases in resting heart rate or blood pressure; no change in plasma potassium or reports of tremor; no haematological or biochemical abnormalities and no adverse events.

CONCLUSION:

We conclude that over 14 days ICI D7114 at a dose level of 150 mg/day has no biologically significant effect on EE in healthy, lean men.

• Authors: G R Goldberg, A M Prentice, P R Murgatroyd, W Haines, M D Tuersley
• Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity (Int J Obes Relat Metab Disord) Vol. 19 Issue 9 Pg. 625-31 (Sep 1995) England
• PMID: 8574272 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Agonists
• Dietary Carbohydrates
• Dietary Fats
• Dietary Proteins
• Phenoxyacetates
• Phenoxypropanolamines
• ICI D7114
• Potassium

Topics

• Adolescent
• Adrenergic beta-Agonists (adverse effects, pharmacology)
• Adult
• Aged
• Blood Pressure (drug effects, physiology)
• Body Mass Index
• Body Weight (drug effects, physiology)
• Calorimetry, Indirect
• Dietary Carbohydrates (metabolism)
• Dietary Fats (metabolism)
• Dietary Proteins (metabolism)
• Double-Blind Method
• Energy Metabolism (drug effects, physiology)
• Heart Rate (drug effects, physiology)
• Humans
• Male
• Middle Aged
• Oxidation-Reduction
• Phenoxyacetates (adverse effects, pharmacology)
• Phenoxypropanolamines
• Potassium (blood)