Abstract | OBJECTIVE: To describe an immunocompromised patient (without AIDS) with nosocomial infectious diarrhea caused by Pseudomonas aeruginosa. Oral ciprofloxacin therapy proved to be effective. CASE SUMMARY: An 80-year-old woman with type II diabetes mellitus and hypertension developed progressive renal insufficiency, was hospitalized because of uremia, and underwent hemodialysis. When the patient developed hematochezia, Duke's C sigmoid colon cancer was detected and successfully resected. She received broad-spectrum antibiotics in the perioperative period. The patient then developed profuse diarrhea associated with abdominal cramping, a low-grade fever, prostration, and headache. The patient then started to received vancomycin 500 mg po qid empirically. Four days later, the diarrhea continued unabated, the Clostridium difficile titer was negative, and the vancomycin therapy was stopped. However, the stool culture was positive for heavy growth of P. aeruginosa sensitive to ciprofloxacin. The patient then began to receive ciprofloxacin 500 mg po bid. Within 3 days the diarrhea stopped. Oral ciprofloxacin therapy was continued for 10 days and the patient remained free of symptoms with formed stools thereafter. DISCUSSION: CONCLUSIONS:
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Authors | F V Porco, E B Visconte |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 29
Issue 11
Pg. 1122-3
(Nov 1995)
ISSN: 1060-0280 [Print] United States |
PMID | 8573957
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Infective Agents
- Ciprofloxacin
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Anti-Infective Agents
(administration & dosage, pharmacology, therapeutic use)
- Ciprofloxacin
(administration & dosage, pharmacology, therapeutic use)
- Cross Infection
(drug therapy, microbiology)
- Diabetes Mellitus, Type 2
(complications)
- Diarrhea
(drug therapy, microbiology)
- Female
- Humans
- Hypertension
(complications)
- Immunocompromised Host
- Pseudomonas Infections
(drug therapy, microbiology)
- Pseudomonas aeruginosa
(isolation & purification)
- Renal Insufficiency
(complications)
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