HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Bilateral acute retinal necrosis in a patient with acquired immunodeficiency syndrome].

Abstract
A case of bilateral progressive outer retinal necrosis occurred after herpes zoster ophthalmicus in a patient with acquired immunodeficiency syndrome. This case does not correspond to the classical picture of progressive outer retinal necrosis. The disease led to blindness despite intravenous therapy with acyclovir and foscarnet. PCR could not identify any virus in the aqueous humour, but VZV is evidenced in cerebrospinal fluid. Acute retinal necrosis is now clearly defined by the American Uveitis Society, which should allow to determine its incidence and risk factors. Herpes zoster usually precedes the acute outer retinal necrosis. The infectious theory (VZV, HSV, CMV) widely prevails over the immune theory. We prefer the virus genome identification in the aqueous humor or in the vitreous by PCR to confirm diagnosis rather than the specific antibody titration. Therapy consists in acyclovir, foscarnet and ganciclovir. But whatever the treatment, the visual prognosis is poor.
AuthorsJ M Menerath, M Gerard, H Laurichesse, P Goldschmidt, H Peigue-Lafeuille, F Rozenberg, J Beytout
JournalJournal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 18 Issue 10 Pg. 625-33 ( 1995) ISSN: 0181-5512 [Print] France
Vernacular TitleNécrose rétinienne aiguë bilatérale chez un patient atteint d'un syndrome d'immunodéficience acquise.
PMID8568169 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Antiviral Agents
Topics
  • Acquired Immunodeficiency Syndrome (complications, therapy)
  • Antiviral Agents (therapeutic use)
  • Herpes Zoster Ophthalmicus (etiology, physiopathology, therapy)
  • Humans
  • Male
  • Middle Aged
  • Retinal Necrosis Syndrome, Acute (etiology, physiopathology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: