Abstract | BACKGROUND & AIMS: METHODS: RESULTS: Rats on the potato starch diet had tumors more frequently and had larger tumors than rats consuming the wheat bran or basic diets. Parallel effects on the density of ACF were found 6 weeks after the carcinogen. Although epithelial proliferation was significantly enhanced by potato starch compared with the basic diet, the addition of wheat bran did not suppress this enhancement. CONCLUSIONS: This type-2 RS enhances epithelial proliferation, ACF density, and tumor formation. The addition of wheat bran to an RS-containing diet suppresses tumorigenesis, acting on events responsible for the formation of ACF but not the events controlling the hyperproliferative phase.
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Authors | G P Young, A McIntyre, V Albert, M Folino, J G Muir, P R Gibson |
Journal | Gastroenterology
(Gastroenterology)
Vol. 110
Issue 2
Pg. 508-14
(Feb 1996)
ISSN: 0016-5085 [Print] United States |
PMID | 8566598
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Dietary Fiber
- Dimethylhydrazines
- Starch
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Topics |
- Analysis of Variance
- Animals
- Carcinogens
(toxicity)
- Cell Count
(drug effects)
- Cell Cycle
(drug effects)
- Colon
(drug effects, pathology)
- Colorectal Neoplasms
(chemically induced, pathology, prevention & control)
- Dietary Fiber
(pharmacology)
- Dimethylhydrazines
- Disease Models, Animal
- Epithelium
(drug effects, pathology)
- Precancerous Conditions
(chemically induced, pathology, prevention & control)
- Random Allocation
- Rats
- Rectum
(drug effects, pathology)
- Solanum tuberosum
- Starch
(toxicity)
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