Improvement of scleredema associated with IgA multiple myeloma after chemotherapy.

Abstract

The presence of a monoclonal gammopathy in patients with chronic scleredema is a recently described, unusual association of unknown significance. There have been very occasional reports of multiple myeloma in such patients. We now report a patient with long-standing scleredema who developed an IgA-kappa multiple myeloma. Once chemotherapy for the myeloproliferative disorder was instituted, scleredema improved significantly, suggesting a pathogenetic link between the two conditions.

• Authors: J A Pujol, M Bueno, M A Fuertes, H Gimenez, F J Carapeto
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 20 Issue 2 Pg. 149-52 (Mar 1995) ISSN: 0307-6938 [Print] England
• PMID: 8565252 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunoglobulin A

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Humans
• Immunoglobulin A (immunology)
• Male
• Multiple Myeloma (complications, drug therapy, pathology, physiopathology)
• Scleroderma, Systemic (complications, pathology, physiopathology)
• Skin (pathology)