HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.

Abstract
The antinflammatory ateroids fluocinoine acetonide, fluocinonide, and fluclorolone acetonide were found to be very effectiveinhibitory agents of mouse skin tumor promotion. These steroids also drastically inhibited epidermal DNA synthesis and epidermal cellular proliferation induced by a phorbal ester tumor promoter. In addition, these compounds were potent inhibitors, of plasminogen activator production in tumor cell cultures. The clinically used non-steroidal antiinflammatory agents oxyphenbutazone, indomethacin, and Seclazone also inhibite tumor promotion but were much less effective. Although these agents are useful against inflammatory disorders in general when given p.o., in our studies they had little effect on inflammation and epidermal cellular proliferation induced by a phorbol ester tumor promoter when given topically. The afore mentioned nonsteroidal antiinflammatory agents also had little effect on epidermal DNA synthesis. Oxyphenbutazone and indomethacin were less potent inhibitors of plasminogen activator production in tumor cells than were the antiinflammatory steroids, and Seclazone produced a negligible inhibition. There is, therefore, a general correlation in the potencies of a series of steroidal antiinflammatory agents for inhibition of tumor promotion and their ability to inhibit plasminogen activator production by tumor cell cultures and epidermal DNA synthesis.
AuthorsA Viaje, T J Slaga, M Wigler, I B Weinstein
JournalCancer research (Cancer Res) Vol. 37 Issue 5 Pg. 1530-6 (May 1977) ISSN: 0008-5472 [Print] United States
PMID856468 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anti-Inflammatory Agents
  • Phorbol Esters
  • Phorbols
  • Fluocinolone Acetonide
  • Fluocinonide
  • DNA
  • Plasminogen Activators
  • Tetradecanoylphorbol Acetate
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Cell Division (drug effects)
  • Cells, Cultured
  • DNA (biosynthesis)
  • Depression, Chemical
  • Female
  • Fluocinolone Acetonide (pharmacology)
  • Fluocinonide (pharmacology)
  • Mice
  • Neoplasms, Experimental (chemically induced)
  • Phorbol Esters (pharmacology)
  • Phorbols (pharmacology)
  • Plasminogen Activators (biosynthesis)
  • Skin (metabolism)
  • Skin Neoplasms (chemically induced)
  • Tetradecanoylphorbol Acetate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: