Abstract |
Serum samples from 72 patients with established carcinoma of the breast were investigated for ectopic presence of hPL. Further, the relationship of ectopically-secreted hPL and hCG-beta in breast cancer was investigated. Ten of 72 patients examined had detectable hPL and 12 had detectable hCG-beta, at 1-2 ng/ml serum sensitivity of the assay. The presence of hPL in serum of breast cancer patients was found to be independent of that of hCG-Beta. Sera of 13 patients with cystic mastitis, five with fibroadenoma, two with acute inflammation of breast, 20 normal women (non-pregnant) and 20 normal men did not show any detectable serum hPL or hCG-beta at the above mentioned sensitivity of the assay. Since these hormones were not detectable in normal men, normal non-pregnant women, and in patients having other pathological conditions of breast, the possible use of them as markers in cancer is expected
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Authors | N A Sheth, J N Suraiya, A R Sheth, K J Ranadive, D J Jussawalla |
Journal | Cancer
(Cancer)
Vol. 39
Issue 4
Pg. 1693-9
(Apr 1977)
ISSN: 0008-543X [Print] United States |
PMID | 856451
(Publication Type: Journal Article)
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Chemical References |
- Chorionic Gonadotropin
- Hormones, Ectopic
- Placental Lactogen
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Topics |
- Adult
- Aged
- Breast Neoplasms
(blood, metabolism, pathology)
- Chorionic Gonadotropin
(blood, metabolism)
- Female
- Hormones, Ectopic
(metabolism)
- Humans
- Middle Aged
- Placental Lactogen
(blood, metabolism)
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