HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Therapeutic efficacy of N-3 polyunsaturated fatty acid in experimental Crohn's disease.

Abstract
We investigated the therapeutic efficacy of n-3 polyunsaturated fatty acids (PUFAs) on trinitro-benzene sulfonic acid (TNBS)-induced colitis in the rats, which condition is considered an experimental Crohn's disease (CD). In rats with TNBS-induced colitis, feeding with an elemental diet (ED) plus 2% n-3 PUEA-rich perilla oil significantly suppressed plasma leukotriene (LT) B4 and ulcer index compared to that in rats fed with ED plus 2% n-6 PUFA-rich safflower oil (34.2 +/- 12.3 s 63.8 +/- 13.2 pg/ml and 8.8 +/- 12.1 vs 66.4 +/- 33.1, P < 0.01, respectively). Moreover, the plasma LTB4 and the ulcer index were significantly correlated (P < 0.05). Feeding with ED plus 2% alpha-linolenic acid (A-LA)-rich vegetable oil significantly reduced plasma LTB4 and colonic weight compared to that in rats fed with ED plus 2% eicosapentaenoic acid (EPA)/docosahexaenonic acid (DHA)-rich fish oil in this model (61.6 +/- 10.5 vs 85.0 +/- 20.9 pg/ml and 0.83 +/- 0.13 vs 0.96 +/- 0.08g, P < 0.05, respectively). This study suggested that dietary fat manipulation with perilla oil can reduce colonic damage and that this is correlated with the suppression of plasma LTB4. The therapeutic efficacy of A-LA in controlling intestinal inflammation in experimental CD may be superior to that of EPA and DHA.
AuthorsR Shoda, K Matsueda, S Yamato, N Umeda
JournalJournal of gastroenterology (J Gastroenterol) Vol. 30 Suppl 8 Pg. 98-101 (Nov 1995) ISSN: 0944-1174 [Print] Japan
PMID8563904 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Fatty Acids, Omega-3
  • Fish Oils
  • alpha-Linolenic Acid
  • Leukotriene B4
  • Safflower Oil
  • Trinitrobenzenesulfonic Acid
Topics
  • Animals
  • Colitis (chemically induced)
  • Colon (pathology)
  • Crohn Disease (chemically induced, therapy)
  • Fatty Acids, Omega-3 (therapeutic use)
  • Fish Oils (therapeutic use)
  • Food, Formulated
  • Leukotriene B4 (blood)
  • Male
  • Organ Size
  • Rats
  • Rats, Sprague-Dawley
  • Safflower Oil (therapeutic use)
  • Trinitrobenzenesulfonic Acid
  • alpha-Linolenic Acid (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: