[Cytopharmacologic effect of using polyvinylpyridine-N-oxide in experimental silicosis].

Abstract

Methods of scanning, transmission electron microscopy and cytochemistry were applied to the study of the development of experimental silicosis against the background of polyvinylpyridine-N-oxide administration. The majority of the macrophages retained their functional activity and realized quartz phagocytosis, eliminating it through the airway. Bringing the proteins on the cell surface in the fibroblasts was delayed, and formation of collagen fibers decreased. Application of the polymere prevented development of fibrosis of the lungs.

• Authors: V D Arutiunov, G G Kruglikov, Iu D Batsura, V I Fedorova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 83 Issue 3 Pg. 371-4 (Mar 1977) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Tsitofarmakologicheskiĭ éffekt primeneniia polivinilpiridin-N-oksida pri éksperimental'nom silikoze
• PMID: 856357 (Publication Type: English Abstract, Journal Article)

Chemical References

• Polyvinyls
• Collagen
• Polyvinylpyridine N-Oxide

Topics

• Animals
• Collagen (metabolism)
• Fibroblasts (metabolism, ultrastructure)
• Histocytochemistry
• Lung (ultrastructure)
• Macrophages (ultrastructure)
• Microscopy, Electron
• Phagocytes (ultrastructure)
• Polyvinylpyridine N-Oxide (therapeutic use)
• Polyvinyls (therapeutic use)
• Rats
• Silicosis (metabolism, pathology, prevention & control)