Abstract |
A controlled study of acute pharmacological intervention was designed to determine whether decreased sympathetic nerve activity in tetraplegic patients results in increased responsiveness of alpha- adrenoceptors which might contribute to vascular hyperreactivity and the clinical scenario of autonomic dysreflexia. The study took place in a university teaching hospital and included six male tetraplegic patients and six age-matched normal male controls. All tetraplegics were 5 months or longer post-traumatic spinal cord injury and all had experienced symptoms of autonomic dysreflexia on at least one occasion. The dorsal foot vein diameter was recorded with a tonometer during local infusions of noradrenaline 0.125-256 ng/min given through a short intravenous needle. In tetraplegic patients, there was a significant shift to the left of the dose-response curve indicating increased venous responsiveness to noradrenaline. The concentration of noradrenaline required to cause a 50% reduction of the resting vein diameter was decreased in tetraplegics (1.6 ng/min, geometric mean) compared to normal controls (10.9 ng/min, p < 0.02). alpha- Adrenoceptor responsiveness in dorsal foot veins is increased in patients with tetraplegia. Hypersensitivity of vascular alpha- adrenoceptors may contribute to autonomic dysreflexia in patients with high spinal cord injury.
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Authors | J M Arnold, Q P Feng, G A Delaney, R W Teasell |
Journal | Clinical autonomic research : official journal of the Clinical Autonomic Research Society
(Clin Auton Res)
Vol. 5
Issue 5
Pg. 267-70
(Oct 1995)
ISSN: 0959-9851 [Print] Germany |
PMID | 8563459
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Adrenergic, alpha
- Norepinephrine
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Topics |
- Adult
- Autonomic Nervous System Diseases
(etiology, physiopathology)
- Blood Pressure
(drug effects)
- Dose-Response Relationship, Drug
- Heart Rate
(drug effects)
- Humans
- Male
- Norepinephrine
(administration & dosage)
- Quadriplegia
(complications, physiopathology)
- Receptors, Adrenergic, alpha
(drug effects, physiology)
- Reflex
(physiology)
- Spinal Cord Injuries
(physiopathology)
- Veins
(anatomy & histology, drug effects, innervation)
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