The treatment of hypercholesterolemia with beta-pyridylcarbinol. Part 5. Report on 16 cases with severe hypercholesterolemia treated for 12 years.

Abstract

A group of 78 patients with severe hypercholesterolemia (-X = 464 mg/dl) and symptoms of vascular disease of the heart, the extremities, or the brain, started a beta-pyridylcarbinol treatment with an average daily dosage of 1.2 g in 1964. In 1976 we could re-examine 12 patients, still on the same therapy. No myocardial infarction has occurred in this group since 1973, only 2 patients have had more attacks of angina pectoris that 1964. In contrast patients discontinuing therapy or replacing beta-pyridylcarbinol by other hypolipidemic drugs had a higher mortality.

• Authors: N Zöllner, C H Keller, G Wolfram
• Journal: Atherosclerosis (Atherosclerosis) Vol. 26 Issue 4 Pg. 611-5 (Apr 1977) ISSN: 0021-9150 [Print] Ireland
• PMID: 856228 (Publication Type: Journal Article)

Chemical References

• Pyridines
• Cholesterol
• Nicotinyl Alcohol

Topics

• Adult
• Aged
• Cholesterol (blood)
• Drug Evaluation
• Female
• Humans
• Hypercholesterolemia (blood, drug therapy, mortality)
• Male
• Middle Aged
• Nicotinyl Alcohol (administration & dosage, therapeutic use)
• Pyridines (therapeutic use)