Pheniramine aminosalicylate overdosage. Reversal of delirium and choreiform movements with tacrine treatment.

Abstract

We describe a case of central anticholinergic syndrome with choreiform movements after an overdose of pheniramine aminosalicylate. The symptoms and signs of the condition were reversed by the intravenous administration of the cholinesterase-inhibitor tetrahydroaminacrine. We also discuss the concept of adrenergic-cholinergic imbalance in relation to this case and recommend the use of centrally acting anticholinesterase agents in the treatment of specific cases of drug overdose.

• Authors: G Mendelson
• Journal: Archives of neurology (Arch Neurol) Vol. 34 Issue 5 Pg. 313 (May 1977) ISSN: 0003-9942 [Print] United States
• PMID: 856127 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acridines
• pheniramine aminosalicylate
• Pheniramine
• Tacrine

Topics

• Acridines (therapeutic use)
• Adolescent
• Chorea (chemically induced, drug therapy)
• Delirium (chemically induced, drug therapy)
• Female
• Humans
• Pheniramine (analogs & derivatives, poisoning)
• Substance-Related Disorders
• Tacrine (therapeutic use)