[The effect of gammaphos on the course and outcome of surgical treatment in combined radiation injuries in pigs].

Abstract

The effect of gamaphos (0.6 mmol kg-1 im, 20 min before irradiation) was investigated upon the course and outcome of the surgical management of combined radiation-gunshot injury in pigs. The hypothesis was tested that the infliction of perforating gunshot injury (LD0/30 days) in pigs in the latent phase of the acute radiation injury (LD0/30 days) results in the increase of the lethal outcome. Gamaphos treatment prevented the lethal outcome. Besides, wound reepithelization and granular tissue vascularization in protected pigs was more intensive in comparison with the unprotected ones.

• Authors: J Cakić, J Dimitrijević, M Simović, O Nanusević, D Durdević, S Milovanović
• Journal: Vojnosanitetski pregled (Vojnosanit Pregl) 1994 May-Jun Vol. 51 Issue 3 Pg. 179-91 ISSN: 0042-8450 [Print] Serbia
• Vernacular Title: Uticaj gamafosa na tok i ishod hirurskog lecenja udruzene radijacione povrede u svinja.
• PMID: 8560830 (Publication Type: English Abstract, Journal Article)

Chemical References

• Radiation-Protective Agents
• Amifostine

Topics

• Acute Disease
• Amifostine (therapeutic use)
• Animals
• Male
• Radiation Injuries, Experimental (complications, pathology)
• Radiation-Protective Agents (therapeutic use)
• Skin (pathology)
• Swine
• Wounds, Gunshot (complications, pathology, surgery)