Phenopyrrozin, a new radical scavenger produced by Penicillium sp. FO-2047.

Abstract

A new radical scavenger, named phenopyrrozin, was isolated from the culture broth of Penicillium sp. FO-2047. Phenopyrrozin was purified from whole broth solvent extraction, silica gel chromatography, and HPLC. The structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-1-phenyl-3H-pyrrolizin-3-one. The IC50 of phenopyrrozin against lipid peroxidation induced by Cr2K2O7 was 73 micrograms/ml. Phenopyrrozin also reduced chromosomal aberrations induced by paraquat.

• Authors: K Shiomi, H Yang, Q Xu, N Arai, M Namiki, M Hayashi, J Inokoshi, H Takeshima, R Masuma, K Komiyama
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 48 Issue 12 Pg. 1413-8 (Dec 1995) ISSN: 0021-8820 [Print] England
• PMID: 8557596 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Free Radical Scavengers
• Mutagens
• Pyrroles
• phenopyrrozin
• Glycoside Hydrolases
• Paraquat

Topics

• Animals
• Anti-Bacterial Agents (biosynthesis, chemistry, pharmacology)
• Chromosome Aberrations
• Cricetinae
• Cricetulus
• Free Radical Scavengers
• Glycoside Hydrolases (antagonists & inhibitors)
• Lipid Peroxidation (drug effects)
• Microbial Sensitivity Tests
• Molecular Structure
• Mutagens (toxicity)
• Paraquat (toxicity)
• Penicillium (classification, metabolism)
• Pyrroles (chemistry, pharmacology)
• Rats
• Spectrum Analysis