Abstract |
Several lines of evidence have suggested that insulin resistance may play an important role in the pathogenesis of hypertension. CS-045 is a new hypoglycemic drug by which improves insulin sensitivity in peripheral tissues. We assessed the effect of CS-045 on hypertension in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) as a control. At 20 weeks of age, the treatment with CS-045 was started by being mixed with chow pellets in the proportion of 0.2% (w/w) and continued for 6 weeks. Nonfasting plasma glucose levels were not changed in either strain of rats treated with CS-045, but plasma insulin levels decreased in SHR 4 and 5 weeks after the start of CS-045 therapy. Blood pressure increased with age in SHR without treatment, but CS-045 decreased blood pressure only 4 and 6 weeks after the treatment. These findings suggest that insulin resistance is not strongly associated with the pathogenesis of hypertension in SHR.
|
Authors | M Kawaguchi, K Tanigawa, Y Kato |
Journal | Endocrine journal
(Endocr J)
Vol. 42
Issue 4
Pg. 557-61
(Aug 1995)
ISSN: 0918-8959 [Print] Japan |
PMID | 8556064
(Publication Type: Journal Article)
|
Chemical References |
- Blood Glucose
- Chromans
- Hypoglycemic Agents
- Insulin
- Thiazoles
- Thiazolidinediones
- Troglitazone
|
Topics |
- Animals
- Blood Glucose
(drug effects, metabolism)
- Blood Pressure
(drug effects)
- Chromans
(therapeutic use)
- Hypertension
(blood, drug therapy, physiopathology)
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(blood)
- Insulin Resistance
- Male
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Thiazoles
(therapeutic use)
- Thiazolidinediones
- Troglitazone
|