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A study of effect of CS-045, a new antidiabetic drug, on hypertension in spontaneously hypertensive rat.

Abstract
Several lines of evidence have suggested that insulin resistance may play an important role in the pathogenesis of hypertension. CS-045 is a new hypoglycemic drug by which improves insulin sensitivity in peripheral tissues. We assessed the effect of CS-045 on hypertension in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) as a control. At 20 weeks of age, the treatment with CS-045 was started by being mixed with chow pellets in the proportion of 0.2% (w/w) and continued for 6 weeks. Nonfasting plasma glucose levels were not changed in either strain of rats treated with CS-045, but plasma insulin levels decreased in SHR 4 and 5 weeks after the start of CS-045 therapy. Blood pressure increased with age in SHR without treatment, but CS-045 decreased blood pressure only 4 and 6 weeks after the treatment. These findings suggest that insulin resistance is not strongly associated with the pathogenesis of hypertension in SHR.
AuthorsM Kawaguchi, K Tanigawa, Y Kato
JournalEndocrine journal (Endocr J) Vol. 42 Issue 4 Pg. 557-61 (Aug 1995) ISSN: 0918-8959 [Print] Japan
PMID8556064 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Chromans
  • Hypoglycemic Agents
  • Insulin
  • Thiazoles
  • Thiazolidinediones
  • Troglitazone
Topics
  • Animals
  • Blood Glucose (drug effects, metabolism)
  • Blood Pressure (drug effects)
  • Chromans (therapeutic use)
  • Hypertension (blood, drug therapy, physiopathology)
  • Hypoglycemic Agents (therapeutic use)
  • Insulin (blood)
  • Insulin Resistance
  • Male
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Thiazoles (therapeutic use)
  • Thiazolidinediones
  • Troglitazone

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