Occupational allergic contact dermatitis from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate in a modified acrylic structural adhesive.

Abstract

Acrylates have a broad area of application in various products including glues, sealants and adhesives. Whereas anaerobic acrylic sealants are well-known sensitizers, acrylate glues that cure in air have only seldom been reported as allergens. Here a patient sensitized to such a glue, and developing hand dermatitis that spread to the lower arms, chest, neck and face, is presented. Her glue was analyzed by gas chromatography/mass spectrometry (GC/MS) and contained 24.6% 2-hydroxyethyl methacrylate (2-HEMA) and 0.4% ethylene glycol dimethacrylate (EGDMA). These 2 acrylate compounds, as well as her glue, provoked an allergic patch test reaction. Also many other acrylate compounds, e.g., tetrahydrofurfuryl methacrylate, gave an allergic reaction indicating cross-allergy. The patient could not continue in her previous workplace because of severely relapsing skin symptoms.

• Authors: L Kanerva, R Jolanki, T Leino, T Estlander
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 33 Issue 2 Pg. 84-9 (Aug 1995) ISSN: 0105-1873 [Print] England
• PMID: 8549149 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adhesives
• Cross-Linking Reagents
• Methacrylates
• Polyurethanes
• hydroxyethyl methacrylate
• ethylene dimethacrylate

Topics

• Adhesives (adverse effects)
• Adult
• Cross Reactions
• Cross-Linking Reagents (adverse effects)
• Dermatitis, Allergic Contact (etiology, physiopathology, therapy)
• Dermatitis, Occupational (etiology, physiopathology, therapy)
• Female
• Hand Dermatoses (chemically induced)
• Humans
• Methacrylates (adverse effects)
• Patch Tests
• Polyurethanes (adverse effects)
• Reference Values