Massive isotretinoin intoxication.

Abstract

We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.

• Authors: S Aubin, G Lorette, C Muller, L Vaillant
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 20 Issue 4 Pg. 348-50 (Jul 1995) ISSN: 0307-6938 [Print] England
• PMID: 8548998 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Isotretinoin

Topics

• Adult
• Drug Overdose
• Humans
• Isotretinoin (poisoning)
• Keratolytic Agents (poisoning)
• Male
• Suicide, Attempted