| Abstract | Effects of monosialoganglioside (GM1 ganglioside) cotreatment with haloperidol (HAL) were studied in rat on the haloperidol treatment-associated changes in cholinergic enzymes, choline acetyltransferase (ChAT), and acetylcholinesterase (AChE) in three brain regions of interest: striatum, hippocampus, and cerebral cortex. Short-term (8 days) haloperidol treatment significantly increased the levels of both ChAT and AChE in all the three regions of brain, as compared with controls (for ChAT: p < .0001 for all comparisons, and for AChE: striatum: p < .0001; hippocampus: p < .0003; cortex: p < .05). Cotreatment with GM1 ganglioside further increased the ChAT activity relative to haloperidol treatment alone in all three regions (p < .05). The AChE activity was also significantly higher than controls in all three regions (p < .05 for all comparisons) and higher than haloperidol treatment only in hippocampus (p < .02). After chronic haloperidol treatment (45 days), ChAT activity in cortex had returned to control values in both HAL and HAL + GM1 groups, with no significant group differences remaining (p = .10). By contrast, relative to control values, HAL and HAL + GM1 groups both showed lower ChAT activity in the striatum, as well as in the hippocampus (p < .0001 for both), with significantly lower ChAT activity in the HAL than in the HAL + GM1 group for both areas (p = < .0001 for both). AChE activity showed a significant difference only between the HAL and HAL + GM1 groups in the cortex (p = .003), but no significant effects of group were seen on AChE activity in either striatum or hippocampus. These data suggest that the protective effects of GM1 ganglioside cotreatment on haloperidol-induced alterations in cholinergic systems can be relevant for protecting against the complications of neuroleptic-induced parkinsonism. |
| Authors | S P Mahadik, S Mukherjee
(Affiliation: Department of Psychiatry and Health Behavior, Medical College of Georgia and Research Service, Veterans Affairs Medical Center, Augusta 30910, USA.)
|
| Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 38
Issue 4
Pg. 246-54
(Aug 15 1995)
ISSN: 0006-3223 UNITED STATES |
| PMID | 8547447
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antipsychotic Agents
- G(M1) Ganglioside
- Haloperidol
- Choline O-Acetyltransferase
|
| Topics |
- Animals
- Antipsychotic Agents
(administration & dosage, analysis, pharmacology)
- Cerebral Cortex
(chemistry, drug effects, enzymology)
- Choline O-Acetyltransferase
(metabolism)
- Corpus Striatum
(chemistry, drug effects, enzymology)
- G(M1) Ganglioside
(administration & dosage, analysis, pharmacology)
- Haloperidol
(administration & dosage, analysis, pharmacology)
- Hippocampus
(chemistry, drug effects, enzymology)
- Male
- Rats
- Rats, Sprague-Dawley
|
