Abstract |
Various bovine ephemeral fever (BEF) vaccines were tested between 1982 and 1984 in 24 Queensland herds; neutralising antibody responses were monitored and six of the herds were closely observed following natural challenge with ephemeral fever. A vaccine regime of two consecutive vaccinations with attenuated virus combined with the adjuvant Quil A provided excellent protection against BEF for at least 12 months, whereas one vaccination with the Quil A vaccine or two vaccinations with vaccine containing the adjuvant aluminium hydroxide gel did not provide significant protection. Antibody responses were highest for the vaccine incorporating Quil A when it was given as two consecutive injections. There was an apparent relationship between neutralising antibody response and the level of protection.
|
Authors | B A Vanselow, J C Walthall, I Abetz |
Journal | Veterinary microbiology
(Vet Microbiol)
Vol. 46
Issue 1-3
Pg. 117-30
(Sep 1995)
ISSN: 0378-1135 [Print] Netherlands |
PMID | 8545949
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Adjuvants, Immunologic
- Antibodies, Viral
- Viral Vaccines
|
Topics |
- Adjuvants, Immunologic
- Animals
- Antibodies, Viral
(biosynthesis, blood)
- Antibody Formation
- Cattle
- Ephemeral Fever
(immunology, prevention & control)
- Ephemeral Fever Virus, Bovine
(immunology)
- Immunization Schedule
- Neutralization Tests
- Queensland
- Safety
- Vaccination
- Viral Vaccines
(administration & dosage, adverse effects)
|