Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia.

Abstract

In a previous paper (Proc. Natl. Acad. Sci. USA 84, 4264, 1987) we reported that a DNA fragment containing a gene for the T-cell receptor beta chain, which had been excised from chromosome 7q35 during D beta-J beta joining, was inserted into chromosome 6p21.3 in a patient with acute T-cell leukemia. We have since screened for genes in the vicinity of the insertion point and have identified a gene that is equivalent to the murine TIS11d gene, a member of TIS11 early response gene family, that contains unique Cysteine-Histidine motifs. The human TIS11d gene consists of two exons and encodes a polypeptide of 492 amino acids. The insertion of the DNA fragment observed in this patient is located at the carboxy-terminal portion of the TIS11d protein.

• Authors: T Ino, H Yasui, M Hirano, Y Kurosawa
• Journal: Oncogene (Oncogene) Vol. 11 Issue 12 Pg. 2705-10 (Dec 21 1995) ISSN: 0950-9232 [Print] England
• PMID: 8545129 (Publication Type: Journal Article)

Chemical References

• DNA-Binding Proteins
• Immediate-Early Proteins
• Proteins
• RNA, Messenger
• Receptors, Antigen, T-Cell, alpha-beta
• Tristetraprolin
• ZFP36 protein, human
• Zfp36 protein, mouse

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Chromosomes, Human, Pair 6
• Conserved Sequence
• DNA-Binding Proteins
• Gene Rearrangement
• Humans
• Immediate-Early Proteins
• Leukemia-Lymphoma, Adult T-Cell (genetics)
• Mice
• Molecular Sequence Data
• Proteins (chemistry, genetics)
• RNA, Messenger (analysis)
• Receptors, Antigen, T-Cell, alpha-beta (genetics)
• Tristetraprolin