Possible mechanisms of action of methotrexate in patients with rheumatoid arthritis.

Abstract

Methotrexate has been reported to be effective in various animal models of arthritis as well as a variety of human disorders without a shared pathogenesis. Reports have emerged of the effect of the drug on lymphocytes, cytokines, leukotrienes, neutrophils, as well as a large variety of intracellular biochemical pathways. At present, it is not possible to identify which of the many possible mechanisms of action are relevant to its action when used in patients with rheumatoid arthritis (RA). More definitive insights may have to await a better understanding of the immunopathogenesis of RA.

• Authors: J M Kremer
• Journal: British journal of rheumatology (Br J Rheumatol) Vol. 34 Suppl 2 Pg. 26-9 (Nov 1995) ISSN: 0263-7103 [Print] England
• PMID: 8535645 (Publication Type: Journal Article, Review)

Chemical References

• Antirheumatic Agents
• Methotrexate

Topics

• Antirheumatic Agents (pharmacology)
• Arthritis, Rheumatoid (drug therapy)
• Humans
• Methotrexate (pharmacology)