Abstract |
Fluorine-18 labeled analog of D- fructose, 1-deoxy-1-[18F]fluoro-D- fructose (1-[18F]FDFrc), was synthesized by nucleophilic substitution of [18F] fluoride ion and the effect of the fluorine substitution on its in vivo metabolism was investigated. The tissue distributions of 1-[18F]FDFrc in rats and tumor bearing mice showed initial high uptake and subsequent rapid washout of the radioactivity in the principal sites of D- fructose metabolism (kidneys, liver and small intestine). The uptakes in the brain and tumor ( fibrosarcoma) were the lowest and moderate, respectively, but tended to increase with time. The in vivo metabolic studies of 1-[18F]FDFrc and nonradioactive 1-FDFrc in mouse brain and tumor showed that the fluorinated analog remained unmetabolized in these tissues, indicating that the substitution of fluorine at the C-1 position produces a nonmetabolizable analog of D- fructose. Thus, 1-[18F]FDFrc had no features of a metabolic trapping tracer without showing any appreciable organ or tumor specific localization.
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Authors | T Haradahira, A Tanaka, M Maeda, Y Kanazawa, Y I Ichiya, K Masuda |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 22
Issue 6
Pg. 719-25
(Aug 1995)
ISSN: 0969-8051 [Print] United States |
PMID | 8535332
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1-deoxy-1-fluorofructose
- Fluorine Radioisotopes
- Indicators and Reagents
- Fructose
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Topics |
- Animals
- Biotransformation
- Brain
(metabolism)
- Fibrosarcoma
(metabolism)
- Fluorine Radioisotopes
- Fructose
(analogs & derivatives, chemical synthesis, metabolism, pharmacokinetics)
- Indicators and Reagents
- Isotope Labeling
(methods)
- Kinetics
- Magnetic Resonance Spectroscopy
- Male
- Mice
- Radioisotope Dilution Technique
- Rats
- Rats, Wistar
- Time Factors
- Tissue Distribution
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