Donor buffy coat infusions for a patient with myelodysplastic syndrome who relapsed following allogeneic bone marrow transplantation.

A 49-year-old man with myelodysplastic syndrome (MDS, RAEB in T) who relapsed following allogeneic bone marrow transplantation (allo BMT) was treated with infusions of donor buffy coat leukocytes. He sustained hematologic and cytogenetic remission, but severe graft-versus-host disease (GVHD) developed for which cyclosporin A and prednisolone were required. This therapeutic approach appears to be valuable for relapsed MDS following allo BMT as well as for chronic myelogenous leukemia (CML).
AuthorsM Tsuzuki, F Maruyama, H Kojima, K Ezaki, M Hirano
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 16 Issue 3 Pg. 487-9 (Sep 1995) ISSN: 0268-3369 [Print] ENGLAND
PMID8535326 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cyclosporine
  • Prednisolone
  • Bone Marrow Transplantation (adverse effects)
  • Cyclosporine (therapeutic use)
  • Graft vs Host Disease (drug therapy)
  • Humans
  • Leukocyte Transfusion
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes (therapy)
  • Prednisolone (therapeutic use)
  • Recurrence

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: