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Impaired myocardial fatty acid metabolism detected by 123I-BMIPP in patients with unstable angina pectoris: comparison with perfusion imaging by 99mTc-sestamibi.

Abstract
The present study was undertaken to determine the potential diagnostic value of 123I-BMIPP scintigraphy for the detection of altered myocardial fatty acid metabolism in patients with unstable angina. Both myocardial metabolic imaging with 123I-BMIPP and perfusion imaging with 99mTc-sestamibi were performed at rest in 28 patients with unstable angina in the pain-free state. The regional uptakes of 123I-BMIPP or 99mTc-sestamibi were scored semiquantitatively (0 = normal, 4 = no activity) and compared with the coronary arteriographic findings. Decreased uptakes of 123I-BMIPP were observed in 18 patients, and 11 patients had abnormal 99mTc-sestamibi images. Defect scores of 123I-BMIPP were larger than those of 99mTc-sestamibi (7.8 +/- 2.1 vs. 5.2 +/- 1.9, p < 0.01). The sensitivity for the detection of patients with unstable angina was higher in 123I-BMIPP than in 99mTc-sestamibi (77% vs. 45%, p < 0.01). The site of the decreased 123I-BMIPP uptake corresponded to the most stenotic coronary artery lesion in all patients. Fatty acid metabolic imaging with 123I-BMIPP was more sensitive for detecting myocardial ischemia than perfusion imaging with 99mTc-sestamibi. 123I-BMIPP may be a clue to define the culprit lesion in unstable angina and be helpful to decide the best treatment and guide coronary angioplasty.
AuthorsY Takeishi, H Sukekawa, H Saito, S Nishimura, T Shibu, Y Sasaki, H Tomoike
JournalAnnals of nuclear medicine (Ann Nucl Med) Vol. 9 Issue 3 Pg. 125-30 (Aug 1995) ISSN: 0914-7187 [Print] JAPAN
PMID8534584 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Decanoic Acids
  • Fatty Acids
  • Iodine Radioisotopes
  • Iodobenzenes
  • iodofiltic acid
  • Technetium Tc 99m Sestamibi
Topics
  • Aged
  • Angina, Unstable (metabolism, radionuclide imaging)
  • Angiocardiography
  • Chi-Square Distribution
  • Decanoic Acids (pharmacokinetics)
  • Echocardiography
  • Fatty Acids (metabolism)
  • Female
  • Heart (radionuclide imaging)
  • Humans
  • Iodine Radioisotopes (pharmacokinetics)
  • Iodobenzenes (pharmacokinetics)
  • Male
  • Myocardium (metabolism)
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi (pharmacokinetics)

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