Impaired myocardial fatty acid metabolism detected by 123I-BMIPP in patients with unstable angina pectoris: comparison with perfusion imaging by 99mTc-sestamibi.

The present study was undertaken to determine the potential diagnostic value of 123I-BMIPP scintigraphy for the detection of altered myocardial fatty acid metabolism in patients with unstable angina. Both myocardial metabolic imaging with 123I-BMIPP and perfusion imaging with 99mTc-sestamibi were performed at rest in 28 patients with unstable angina in the pain-free state. The regional uptakes of 123I-BMIPP or 99mTc-sestamibi were scored semiquantitatively (0 = normal, 4 = no activity) and compared with the coronary arteriographic findings. Decreased uptakes of 123I-BMIPP were observed in 18 patients, and 11 patients had abnormal 99mTc-sestamibi images. Defect scores of 123I-BMIPP were larger than those of 99mTc-sestamibi (7.8 +/- 2.1 vs. 5.2 +/- 1.9, p < 0.01). The sensitivity for the detection of patients with unstable angina was higher in 123I-BMIPP than in 99mTc-sestamibi (77% vs. 45%, p < 0.01). The site of the decreased 123I-BMIPP uptake corresponded to the most stenotic coronary artery lesion in all patients. Fatty acid metabolic imaging with 123I-BMIPP was more sensitive for detecting myocardial ischemia than perfusion imaging with 99mTc-sestamibi. 123I-BMIPP may be a clue to define the culprit lesion in unstable angina and be helpful to decide the best treatment and guide coronary angioplasty.
AuthorsY Takeishi, H Sukekawa, H Saito, S Nishimura, T Shibu, Y Sasaki, H Tomoike
JournalAnnals of nuclear medicine (Ann Nucl Med) Vol. 9 Issue 3 Pg. 125-30 (Aug 1995) ISSN: 0914-7187 [Print] JAPAN
PMID8534584 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Decanoic Acids
  • Fatty Acids
  • Iodine Radioisotopes
  • Iodobenzenes
  • iodofiltic acid
  • Technetium Tc 99m Sestamibi
  • Aged
  • Angina, Unstable (metabolism, radionuclide imaging)
  • Angiocardiography
  • Chi-Square Distribution
  • Decanoic Acids (pharmacokinetics)
  • Echocardiography
  • Fatty Acids (metabolism)
  • Female
  • Heart (radionuclide imaging)
  • Humans
  • Iodine Radioisotopes (pharmacokinetics)
  • Iodobenzenes (pharmacokinetics)
  • Male
  • Myocardium (metabolism)
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi (pharmacokinetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: