Effect of long-term administration of a prolonged release formulation of bovine somatotropin (sometribove) on clinical lameness in dairy cows.

Abstract

A matched case-control study design was used to assess the effects of long-term administration of a prolonged release formulation of bovine somatotropin (sometribove) on clinical lameness and limb lesions in dairy cows. Cows treated with sometribove for at least 2 lactations (cases) and nontreated dairy cows matched by herd, parity, age, and stage of lactation (controls) in 8 herds were evaluated for clinical lameness (as assessed by gait abnormality) and limb lesions by 2 observers, using a standardized scoring procedure at a single herd visit. Although a high proportion of the study cows were clinically lame (43%), an association was not detected between chronic administration of sometribove and prevalent lameness. Of 21 types of limb lesions identified, 2 were positively associated and 2 were negatively associated with long-term sometribove use. Superficial laceration of the tarsus (odds ratio [OR] = 2.1) and superficial swelling of the metatarsophalangeal joint (OR = 4.5) were positively associated with sometribove treatment, whereas femoral lesions (OR = 0.2) and superficial lacerations of the femur (OR = 0.14) were negatively associated with sometribove treatment.

• Authors: S J Wells, A M Trent, R J Collier, W J Cole
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 56 Issue 8 Pg. 992-6 (Aug 1995) ISSN: 0002-9645 [Print] United States
• PMID: 8533990 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Growth Hormone
• sometribove

Topics

• Age Factors
• Animals
• Cattle
• Cattle Diseases (chemically induced)
• Dairying
• Delayed-Action Preparations
• Female
• Gait (physiology)
• Growth Hormone (administration & dosage, adverse effects)
• Lameness, Animal (chemically induced)
• Parity
• Time Factors