Abstract |
Endothelin-1 (ET-1) is a vasoactive, mitogenic peptide that is variably increased in Bronchoalveolar Lavage Fluid (BALF) and immunohistochemically found in lung tissue of patients with Interstitial Lung Disease (ILD). To assess if endogenous ET-1 production is increased in ILD we evaluated 24 hour (24h) urine excretion of ET-1 in 20 patients with ILD and 10 healthy age-matched controls (HC). Eight patients with active pulmonary sarcoidosis ( S), 6 with idiopathic pulmonary fibrosis (IPF) and 6 with focal lung fibrosis due to inactive pulmonary tuberculosis ( hTB) were studied. Plasma ET-1 levels (ET-1pl, pg/ml) and 24h ET-1 levels in urine (ET-1ur, ng/24h) were measured by a specific radio-immunoassay. Determinations of ET-1p1 and ET-1ur were repeated in S and IPF patients after 30 days of prednisone (0.75 mg/kg/day) treatment. ET-1p1 concentrations were not different between HC (5.34 +/- 0.48), S (5.95 +/- 0.96), IPF (4.75 +/- 1.37) and hTB (5.97 +/- 1.05) groups. ET-1ur was significantly higher in S (189.50 +/- 60.57) than in HC (69.00 +/- 10.76), IPF (62.17 +/- 19.07) and hTB (82.00 +/- 24.97). After prednisone, ET-1ur in the S group decreased significantly (189.50 +/- 60.57 to 94.00 +/- 13.60), and the decrease paralleled the improved clinical status. In S patients, ET-1ur was not significantly correlated to the degree of respiratory impairment, but it was significantly correlated to the intensity of lymphocytic alveolitis (r = 0.80).(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | M Sofia, M Mormile, S Faraone, M Alifano, P Carratù, L Carratù |
Journal | Sarcoidosis
(Sarcoidosis)
Vol. 12
Issue 2
Pg. 118-23
(Sep 1995)
ISSN: 0393-1447 [Print] Italy |
PMID | 8532958
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Endothelins
- Prednisone
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Topics |
- Adult
- Biomarkers
(urine)
- Endothelins
(urine)
- Female
- Humans
- Lung Diseases, Interstitial
(drug therapy, urine)
- Male
- Middle Aged
- Prednisone
(therapeutic use)
- Sarcoidosis, Pulmonary
(urine)
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