[CD5-negative B-cell chronic lymphocytic leukemia (B-CLL) associated with massive splenomegaly and without lymphadenopathy].

Abstract

A 39-year-old male was referred to our hospital in June, 1993, because of leukocytosis. Physical examinations showed massive splenomegaly without any lymphadenopathy. The white blood cell count was 13,800/microliters with 87% morphologically mature lymphocytes. Bone marrow aspirate revealed hypercellularity with 67% lymphocytes morphologically similar to peripheral lymphocytes. The lymphocytes displayed monoclonal rearrangements of immunoglobulin genes and the phenotype of CD5-CD19+CD20+ CD21+ and Smlg+. Splenectomy was effective against neutropenia and thromboytopenia. The clinical and laboratory findings of this case were unusual compared to those of typical B-CLL in massive splenomegaly, no lymphadenopathy and CD5-phenotype, suggesting the heterogeneity of B-CLL.

• Authors: T Yamada, H Ninomiya, T Horiuchi, K Takada, T Hato, K Yamauchi, M Yasukawa, S Fujita
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 36 Issue 10 Pg. 1230-2 (Oct 1995) ISSN: 0485-1439 [Print] Japan
• PMID: 8531336 (Publication Type: Case Reports, Journal Article)

Chemical References

• CD5 Antigens
• Immunoglobulins

Topics

• Adult
• CD5 Antigens (immunology)
• Gene Rearrangement
• Humans
• Immunoglobulins (genetics)
• Leukemia, Lymphocytic, Chronic, B-Cell (complications, genetics, immunology)
• Lymphatic Diseases
• Male
• Splenomegaly (complications, surgery)