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Oral diclofenac in the prophylactic treatment of recurrent renal colic. A double-blind comparison with placebo.

Abstract
We have conducted a double-blind, randomized, placebo-controlled trial with oral diclofenac to study the prophylactic effect on renal colic recurrence and spontaneous stone expulsion rate. Forty-one patients were given 50 mg oral diclofenac 3 times a day for 7 days after being discharged for a colic episode from Oslo Emergency Hospital (< 24 h stay) and 39 patients were given matching placebo tablets. The number of new renal colic episodes per accumulated patient treatment days was 64/287 in the diclofenac group and 119/273 in the placebo group (p < 0.01). This difference was greatest during the first 4 treatment days. A similar trend was found for pain intensity (0-10 cm VAS) with the greatest difference on day 1 (4.3 vs. 2.8, p = 0.05). Side effects, mainly gastrointestinal, were reported for 14% of the treatment days in both treatment groups. Stone expulsion rate was almost identical (28 vs. 29 days), regardless of stone size. Readmission rate to Oslo Emergency Hospital/other hospitals were 10 and 67% (p < 0.001). In conclusion, oral treatment with diclofenac was effective as short-term prophylaxis of new colic episodes, especially during the first 4 days, and reduces the number of hospital readmissions significantly. The stone passage rate appears not to be affected.
AuthorsE Laerum, O E Ommundsen, J E Grønseth, A Christiansen, H E Fagertun
JournalEuropean urology (Eur Urol) Vol. 28 Issue 2 Pg. 108-11 ( 1995) ISSN: 0302-2838 [Print] Switzerland
PMID8529732 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Cyclooxygenase Inhibitors
  • Placebos
  • Diclofenac
  • Indomethacin
Topics
  • Administration, Oral
  • Adult
  • Analysis of Variance
  • Colic (drug therapy)
  • Cyclooxygenase Inhibitors (administration & dosage, therapeutic use)
  • Diclofenac (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Indomethacin (administration & dosage, therapeutic use)
  • Kidney Calculi (drug therapy)
  • Male
  • Placebos
  • Recurrence

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