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Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat.

Abstract
In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on the growth of implanted fibrosarcoma in the rat. We found that the growth rate of the tumor was significantly retarded by daily oral administration of ferrous sulfate followed by dihydroartemisinin. No significant tumor growth retardation effect was observed in rats treated with either dihydroartemisinin or ferrous sulfate alone. The drug treatment did not significantly affect body weight compared with untreated tumor-implanted animals and no apparent toxic effect was observed after drug treatment. An artemisinin analog-ferrous salt combination may provide a novel approach for cancer therapy.
AuthorsJ C Moore, H Lai, J R Li, R L Ren, J A McDougall, N P Singh, C K Chou
JournalCancer letters (Cancer Lett) Vol. 98 Issue 1 Pg. 83-7 (Nov 27 1995) ISSN: 0304-3835 [Print] Ireland
PMID8529210 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Artemisinins
  • Ferrous Compounds
  • Reactive Oxygen Species
  • Sesquiterpenes
  • ferrous sulfate
  • artenimol
Topics
  • Administration, Oral
  • Animals
  • Antineoplastic Agents, Phytogenic (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Artemisinins
  • Female
  • Ferrous Compounds (administration & dosage)
  • Fibrosarcoma (drug therapy)
  • Neoplasm Transplantation
  • Rats
  • Rats, Inbred F344
  • Reactive Oxygen Species (administration & dosage)
  • Sesquiterpenes (administration & dosage)

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